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Cold plasma in the correction of involutional skin changes: clinical experience

Skin aging is the first visually significant sign of involutional changes occurring in the body.

There are two main types of aging: chronological and photoaging (external), although recently such a division is becoming less common. At the same time, much attention is paid to the so-called exposure factors – a complex of different effects on the human body from the moment of birth and throughout life.

Chronological aging (according to Zouboulis C., Makrantonaki E., 2010) is characterized by:

10–50% reduction in the total thickness of the epidermis
atrophy of the prickly layer,
reduction in size and flattening of the cells of the basal layer
decreased mitotic activity of basal keratinocytes
decrease in lipid renewal processes
flattening of the dermoepidermal compound
decrease in the number and heterogeneity of melanocytes
decrease in the number of Langerhans cells
In the dermis, with this type of aging, the number of fibroblasts decreases, atrophy of the intercellular matrix occurs, disintegration of collagen and elastic fibers and their reduction. These involutional changes lead to a disorganization of proliferation and exfoliation processes, as well as activation of deformation processes and the formation of wrinkles.

Morphological and functional signs of photoaging of the skin (according to Zouboulis C., Makrantonaki E., 2010) include changes in the epidermis and dermis. But the main difference between photoaging and chronological (true) aging is the failure of the desquamation process, an increase in the life cycle of corneocytes, which leads to a thickening of the stratum corneum and epidermis. A decrease in the synthesis of filaggrin protein in the granular layer leads to transepidermal water loss, which causes dry skin and the appearance of superficial wrinkles. In the dermis, there is a decrease in the number and size of fibroblasts, the volume of intercellular substance, the process of elastolysis is activated. It is worth noting that the ability of the dermis to synthesize collagen and other components of the intercellular substance of the dermis is preserved, therefore, many signs of photoaging are reversible. Visually photoaging is characterized by the appearance of spider veins, age spots (lentigo), and profuse wrinkles.

What is the peculiarity of cold plasma?
A new non-invasive method, in the form of a complex effect of ions, electrons, photons and neutrals (radicals, as well as excited atoms and molecules), is cold (low-temperature) plasma (NTP).

Hardware capabilities of low-temperature plasma
NTP is devoid of the lack of other methods of therapeutic effect – high concentrations of toxic components. The main active components here are electrons, ions, free radicals and light. Free radicals are especially important in the induction of the physiological functions of cells and tissues. The active forms of oxygen and nitrogen formed under the action of “cold” plasma play a very important role in both physiological and pathological processes that occur in various cells of the body. In recent years, NTP has been used in regenerative medicine. The low-intensity effect of NTP significantly enhances cell growth and proliferation. The disorganization of proliferation and exfoliation processes underlies changes in skin quality.

Clinical Experience and Results

Ph.D., dermatovenerologist, associate professor of the Department of Dermatovenerology. RNIMU named after N.I. Pirogov, Moscow
We conducted research on the possibility of using NTP to improve the condition of the skin of the face with its involutional changes as anti-aging therapy. The source of NTP for research was the Helios apparatus (medical registration certificate No. RZN 2016/4374 dated 04/04/2016).

The condition of the facial region of all study participants was regarded as the 3rd morphotype of involutional changes (face pastiness, drooping mouth corners, severity of wrinkles in the corners of the eyes (crow’s feet), in the eyebrow region, purse-string wrinkles in the upper lip area).

An ultrasound examination of the skin of the face showed significant deformation of the microrelief, thickening of the epidermis while maintaining a clear border of the epidermis and dermis.

After completing the course of exposure of the Helios apparatus to NTP on the skin of the face, all study participants showed a positive trend in the form of a decrease in the deformation of the microrelief, a decrease in the ultrasonic density of the epidermis and dermis, and a tendency to increase the average thickness of the dermis. The greatest changes were observed from the microrelief in the area of ​​“crow’s feet”, which became more smoothed. A decrease in the ultrasonic density of the epidermis indicated a decrease in the thickness of the stratum corneum of the epidermis, an improvement in microcirculation and the quality of the hydrolipidic mantle of the skin.

We purchased the Helios Apparatus a year ago, in May 2018, we always carefully study the operating principle of the apparatus, and more and more we are convinced of the correct choice of technology. A cold plasma beam gently affects the skin of a person without causing burns. The Helios device is considered therapeutic. A gentle blue ray has a temperature of 35–45 degrees and leaves no residue after exposure.

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